Gynecology & Obstetrics Research (ISSN: XXXX-XXXX)

Therapeutic applications of recent advancements in insight regarding mechanisms of development of Anorexia Nervosa: implications in the management and development of biomarkers for early detection besides avoidance of neonatal malformations-A Short Comm
Authors: Kulvinder Kochar Kaur M.D., Gautam Allahbadia M.D., Mandeep Singh M.D.

Earlier we had reviewed regarding how patients of AN who present with primary/secondary hypothalamic amenorrhoea were markedly recalcitrant to any forms of treatment besides deficiency in reward appreciation Furthermore, we concentrated on the pathophysiology of obesity along with its association with type2 diabetes mellitus(T2DM) besides non-alcoholic fatty liver disease(NAFLD)along with other co-morbidities, like heart failure, adiposity, Metabolic Syndrome&role of GutMicrobiota/besides role of pro as well as prebiotics, with Faecal microbiota transplantation(FMT) for their treatment. Here we have focused on the latest research carried out in an eating disorder called Anorexia Nervosa(AN) which we had earlier reviewed in association with hypothalamic amenorrhea as a psychiatric condition correlated with extreme anorexia, besides excessive exercise occasionally that usually brought young girls to us with amenorrhea. It had been an illunderstood condition that was markedly resistant to any treatment. Extensive research carried out recently has revealed its association with other psychiatric conditions like depression, anxiety as well as post-traumatic stress disorder (PTSD) along with altered nutrition profile with lower fiber intake thus correlated with lower CRP, whereas that with high saturated FattyAcids(FA) with greater CRP as seen with the Mediterranean diet that we commonly advocatefor obese patients. Here we further detail how these advancement aid in treating such patients with the knowledge that the pathophysiology behind the development of these disorders lies in the alterations in various proinflammatory cytokines besides chemokines in AN,thus the association of inflammation besides neuroinflammation explaining the coexistence of psychiatric disorders in AN.These insights aid in planning innovative treatments for such disorders besides ensuring a smooth marriage, pregnancy and child birth. FMT might aid in treating patients that are markedly resistant to any treatment in view of the presence of altered gut microbiotain AN like in obesity.

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